Таблетки Зеродол инструкция по применению, отзывы, аналоги

Paracetamol Zerodol P interactions

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With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic Paracetamol (Zerodol P) of Paracetamol (Zerodol P).

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Paracetamol (Zerodol P).

With the simultaneous use of oral contraceptives accelerated excretion of Paracetamol (Zerodol P) from the body and may reduce its analgesic Paracetamol (Zerodol P).

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Paracetamol (Zerodol P).

When Paracetamol (Zerodol P) Guardian applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Paracetamol (Zerodol P). A case of severe toxic liver injury.

Described cases of toxic effects of Paracetamol (Zerodol P), while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Paracetamol (Zerodol P), which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Paracetamol (Zerodol P) and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Paracetamol (Zerodol P) may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Paracetamol (Zerodol P) and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Paracetamol (Zerodol P), with rifampicin, sulfinpyrazone — may increase clearance of Paracetamol (Zerodol P) due to increasing its metabolism in the liver.

At simultaneous application of Paracetamol (Zerodol P) Guardian with ethinylestradiol increases absorption of Paracetamol (Zerodol P) from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce — rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Paracetamol Zerodol P side effects

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The following serious adverse reactions are discussed elsewhere in the labeling:

  • Hepatic Injury
  • Serious Skin Reactions
  • Allergy and Hypersensitivity

Clinical Trial Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in practice.

Adult Population

A total of 1020 adult patients have received Paracetamol (Zerodol P) in clinical trials, including 37.3% (n=380) who received 5 or more doses, and 17.0% (n=173) who received more than 10 doses. Most patients were treated with Paracetamol (Zerodol P) 1000 mg every 6 hours. A total of 13.1% (n=134) received Paracetamol (Zerodol P) 650 mg every 4 hours.

All adverse reactions that occurred in adult patients treated with either Paracetamol (Zerodol P) or placebo in repeated dose, placebo-controlled clinical trials at an incidence ≥ 3% and at a greater frequency than placebo are listed in Table 3. The most common adverse events in adult patients treated with Paracetamol (Zerodol P) (incidence ≥ 5% and greater than placebo) were nausea, vomiting, headache, and insomnia.

Table 3. Treatment-Emergent Adverse Reactions Occurring ≥ 3% of Paracetamol (Zerodol P)-treated Patients and at a greater frequency than Placebo in Placebo-Controlled, Repeated Dose Studies

* Pyrexia adverse reaction frequency data is included in order to alert healthcare practitioners that the antipyretic effects of Paracetamol (Zerodol P) may mask fever.

System Organ Class – Preferred Term Paracetamol (Zerodol P)

(N=402)

n (%)

Placebo

(N=379)

n (%)

Gastrointestinal Disorders

Nausea

Vomiting

138 (34)

62 (15)

119 (31)

42 (11)

General Disorders and Administration Site Conditions

Pyrexia*

22 (5) 52 (14)
Nervous System Disorders

Headache

39 (10) 33 (9)
Psychiatric Disorders

Insomnia

30 (7) 21 (5)

Other Adverse Reactions Observed During Clinical Studies of Paracetamol (Zerodol P) in Adults

The following additional treatment-emergent adverse reactions were reported by adult subjects treated with Paracetamol (Zerodol P) in all clinical trials (n=1020) that occurred with an incidence of at least 1% and at a frequency greater than placebo (n=525).

Blood and lymphatic system disorders: anemia

General disorders and administration site conditions: fatigue, infusion site pain, edema peripheral

Investigations: aspartate aminotransferase increased, breath sounds abnormal

Metabolism and nutrition disorders: hypokalemia

Musculoskeletal and connective tissue disorders: muscle spasms, trismus

Psychiatric disorders: anxiety

Respiratory, thoracic and mediastinal disorders: dyspnea

Vascular disorders: hypertension, hypotension

Pediatric Population

A total of 355 pediatric patients (47 neonates, 64 infants, 171 children, and 73 adolescents) have received Paracetamol (Zerodol P) in active-controlled (n=250) and open-label clinical trials (n=225), including 59.7% (n=212) who received 5 or more doses and 43.1% (n=153) who received more than 10 doses. Pediatric patients received Paracetamol (Zerodol P) doses up to 15 mg/kg on an every 4 hours, every 6 hours, or every 8 hours schedule. The maximum exposure was 7.7, 6.4, 6.8, and 7.1 days in neonates, infants, children, and adolescents, respectively.

The most common adverse events (incidence ≥ 5%) in pediatric patients treated with Paracetamol (Zerodol P) were nausea, vomiting, constipation, pruritus, agitation, and atelectasis.

Other Adverse Reactions Observed During Clinical Studies of Paracetamol (Zerodol P) in Pediatrics

The following additional treatment-emergent adverse reactions were reported by pediatric subjects treated with Paracetamol (Zerodol P) (n=355) that occurred with an incidence of at least 1%.

Blood and lymphatic system disorders: anemia

Cardiac disorders: tachycardia

Gastrointestinal disorders: abdominal pain, diarrhea

General disorders and administration site conditions: injection site pain, edema peripheral, pyrexia

Investigations: hepatic enzyme increase

Metabolism and nutrition disorders: hypoalbuminemia, hypokalemia, hypomagnesemia, hypophosphatemia, hypervolemia

Musculoskeletal and connective tissue disorders: muscle spasm, pain in extremity

Nervous system disorders: headache

Psychiatric disorders: insomnia

Renal and urinary disorders: oliguria

Respiratory, thoracic and mediastinal disorders: pulmonary edema, hypoxia, pleural effusion, stridor, wheezing

Skin and subcutaneous tissue disorders: periorbital edema, rash

Vascular disorders: hypertension, hypotension

Paracetamol Zerodol P indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or Paracetamol (Zerodol P) is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of Paracetamol (Zerodol P). A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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For systemic use of Paracetamol (Zerodol P) Sante Naturelle: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

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Reviews

User reports

1 consumer reported useful

Was the Zerodol P drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used , other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.

Users %
Useful 1 100.0%

1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Zerodol P drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.

Users %
Not expensive 1 100.0%

5 consumers reported time for results

To what extent do I have to use Zerodol P before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 3 days and a few days before you notice an improvement in your health conditions.Please note, it doesn’t mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Zerodol P. To get the time effectiveness of using Zerodol P drug by other patients, please click here.

Users %
3 days 2 40.0%
3 month 1 20.0%
1 month 1 20.0%
1 day 1 20.0%

46 consumers reported age

Users %
6-15 24 52.2%
16-29 11 23.9%
30-45 6 13.0%
1-5 4 8.7%
46-60 1 2.2%
There are no reviews yet. Be the first to write one!

Information checked by Dr. Sachin Kumar, MD Pharmacology

Paracetamol Zerodol P description

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Paracetamol (Zerodol P) is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Paracetamol (Zerodol P) exists as small alkaline deliquescent crystals with a saline tasteacinol was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successfulacinol was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic Paracetamol (Zerodol P). Their mode of Paracetamol (Zerodol P) is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.

How should I use Paracetamol Zerodol P

Use Paracetamol (Zerodol P) exactly as directed on the label, or as prescribed by your doctor.

Do not use more of this medication than is recommended. An overdose of Paracetamol (Zerodol P) can cause serious harm. The maximum amount for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Using more Paracetamol (Zerodol P) could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking Paracetamol (Zerodol P) and never use more than 2 grams (2000 mg) per day. If you are treating a child, use a pediatric form of Paracetamol (Zerodol P). Carefully follow the dosing directions on the medicine label. Do not give the medication to a child younger than 2 years old without the advice of a doctor.

Measure the liquid form of Paracetamol (Zerodol P) with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. You may need to shake the liquid before each use. Follow the directions on the medicine label.

The Paracetamol (Zerodol P) chewable tablet must be chewed thoroughly before you swallow it.

Make sure your hands are dry when handling the Paracetamol (Zerodol P) disintegrating tablet. Place the tablet on your tongue. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

To use the Paracetamol (Zerodol P) effervescent granules, dissolve one packet of the granules in at least 4 ounces of water. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

Do not take a Paracetamol (Zerodol P) rectal suppository by mouth. It is for use only in your rectum. Wash your hands before and after inserting the suppository.

Try to empty your bowel and bladder just before using the Paracetamol (Zerodol P) suppository. Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

For best results from the suppository, lie down and insert the suppository pointed tip first into the rectum. Hold in the suppository for a few minutes. It will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after inserting the suppository.

Stop using Paracetamol (Zerodol P) and call your doctor if:

  • you still have a fever after 3 days of use;

  • you still have pain after 7 days of use (or 5 days if treating a child);

  • you have a skin rash, ongoing headache, or any redness or swelling; or

  • if your symptoms get worse, or if you have any new symptoms.

Urine glucose tests may produce false results while you are taking Paracetamol (Zerodol P). Talk to your doctor if you are diabetic and you notice changes in your glucose levels during treatment.

Store Paracetamol (Zerodol P) at room temperature away from heat and moisture. The rectal suppositories can be stored at room temperature or in the refrigerator.

Uses of Paracetamol Zerodol P in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.

How to use Paracetamol (Zerodol P)

Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

There are many brands and forms of acetaminophen available. Read the dosing instructions carefully for each product because the amount of acetaminophen may be different between products. Do not take more acetaminophen than recommended.

If you are giving acetaminophen to a child, be sure you use a product that is meant for children. Use your child’s weight to find the right dose on the product package. If you don’t know your child’s weight, you can use their age.

For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.

For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.

Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.

Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.

Стаж работы Ярослава составляет 25 лет, из них 15 лет в клинической травматологии. Закончив лечебный факультет, одного из крупнейших медицинских вузов СССР в 1982 г., Ярослав Филатов проходил многочисленные усовершенствования и повышения квалификации, последняя из них пройдена в 2017 г.
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