Dexofen contraindications
Absolute Contraindications:Not to be given to those patients who have history of stroke (cerebrovascular accident), heart attack (myocardial infarction), coronary artery bypass graft, uncontrolled hypertension, congestive heart failure (CHF) NYHA II-IV.
Contraindications:Dexofen must not be administered in the following cases: Patients hypersensitive to Dexofen, to any other NSAID, or to any of the excipients of Dexofen; patients in whom substances with a similar action (eg, aspirin or other NSAIDs) precipitate attacks of asthma, bronchospasm, acute rhinitis, or cause nasal polyps, urticaria or angioneurotic edema; patients with active or suspected peptic ulcer/hemorrhage or history of recurrent peptic ulcer/hemorrhage (≥2 distinct episodes of proven ulceration or bleeding) or chronic dyspepsia; history of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy; gastrointestinal bleeding or other active bleedings or bleeding disorders; Crohn’s disease or ulcerative colitis; history of bronchial asthma; severe heart failure; moderate to severe renal dysfunction (CrCl
Injection: Dexofen solution for injection or concentrate for solution for infusion is contraindicated for neuraxial (intrathecal or epidural) administration due to its ethanol content.
Use in Pregnancy & Lactation: Not to be used during the 3rd trimester of pregnancy and lactation period.
During the 3rd trimester of pregnancy, all prostaglandin synthesis inhibitors may expose the fetus to cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension) and renal dysfunction, which may progress to renal failure with oligo-hydroamniosis.
At the end of pregnancy, all prostaglandin synthesis inhibitors may expose the mother and the neonate to possible prolongation of bleeding time, an anti-aggregating effect which may occur even at very low doses and inhibition of uterine contractions resulting in delayed or prolonged labor. Consequently, Dexofen trometamol is contraindicated during the 3rd trimester of pregnancy.
It is not known whether Dexofen is excreted in human milk.
Use in Children: Dexofen has not been studied in children and adolescents. Therefore, safety and efficacy have not been established and Dexofen should not be used in children and adolescents.
Uses of Dexofen in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
Dexofen is used in the treatment of mild to moderate pain such as such as muscular pain, painful menstrual periods (dysmenorrhoea) and toothache.
Reviews
User reports
3 consumers reported useful
Was the Dexofen drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used , other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 3 | 100.0% |
1 consumer reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Dexofen drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 1 | 100.0% |
3 consumers reported time for results
To what extent do I have to use Dexofen before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.Please note, it doesn’t mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Dexofen. To get the time effectiveness of using Dexofen drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 day | 2 | 66.7% | |
| 1 week | 1 | 33.3% |
20 consumers reported age
| Users | % | ||
|---|---|---|---|
| 16-29 | 12 | 60.0% | |
| > 60 | 4 | 20.0% | |
| 46-60 | 2 | 10.0% | |
| 30-45 | 1 | 5.0% | |
| 1-5 | 1 | 5.0% |
Consumer reviews
| Cecilia Elisabeth | 04 Oct 2017 13:55 |
| As far as I know the medication is banned (at least in Sweden) because it\’s now classified as poison. I remember being prescribed this drug back in 2010-it then said on the list of side- effects (and so on) that you could die if you had had any alcohol 24 hours before taking medication, and 48 hours afterwards. The reason being, complete cramp and ultimately a type of suffocation in your respiratory system. It also said that you could not under any circumstance drive — I could barely stand up for more than 10 minutes without fainting. This drug is REALLY dangerous. | |
| michael burberry | 20 Jul 2017 03:07 |
| Dexofen is banned in the United and States and European Union. Why? |
Information checked by Dr. Sachin Kumar, MD Pharmacology
Active ingredient matches for Dexofen
Dexketoprofen in Bulgaria, Sweden.
| Sort by popularity | |
| Unit description / dosage (Manufacturer) | Price, USD |
| Dexmol (Turkey) | |
| Dexoket (Czech Republic) | |
| Dexomen (Bosnia & Herzegowina, Serbia) | |
| Dexomen 12.5 (Serbia) | |
| Dexomen 25 (Serbia) | |
| Dexpain (Indonesia) | |
| Dextanol (Georgia) | |
| Dextrafast (Egypt) | |
| Dextropropoxyphene Napsilate | |
| Dktrom (Guatemala) | |
| Dolmen (Estonia, Italy, Latvia, Lithuania) | |
| Elektra Fort (Turkey) | |
| Enangel (Spain) | |
| Enantyum (Argentina, Austria, Costa Rica, Dominican Republic, El Salvador, Germany, Guatemala, Honduras, Italy, Luxembourg, Nicaragua, Panama, Spain) | |
| Enantyum 25 mg (Austria, Hungary) | |
| Fen Li (China) | |
| Grot (Turkey) | |
| Hopaxiam (Colombia) | |
| Idolgina (Argentina) | |
| INFEN (Myanmar) | |
| 25 mg x 10’s (Emcure) | $ 0.49 |
| INFEN 1.25% W/W GEL 1 tube / 30 GM gel each (Emcure) | $ 1.59 |
| INFEN tab 25 mg x 10’s (Emcure) | $ 0.49 |
| Infen 1.25% w/w Gel (Emcure) | $ 1.59 |
| Infen 25mg Tablet (Emcure) | $ 0.08 |
| Infen 25 (Myanmar) | |
| Infen 25 FC tab 25 mg 10’s (Emcure) | |
| INFEN OD | |
| INFEN OD 75 MG TABLET 1 strip / 10 tablets each (Emcure Pharmaceuticals Ltd) | $ 1.84 |
| INFEN-OD (India) | |
| INFEN-OD ER tab 75 mg x 10’s (Emcure) | $ 1.52 |
| Keral (Ireland, Malta, Mexico, United Kingdom) | |
| Tablet, Film-Coated; Oral; Dexketoprofen Tromethamine 25 mg (Menarini) | |
| Ketavel (Turkey) | |
| Ketesgel (Spain) | |
| Ketesse (Colombia, Denmark, Estonia, Finland, France, Indonesia, Italy, Latvia, Lithuania, Luxembourg, Peru, Poland, Portugal, Slovakia, Slovenia, Spain, Switzerland) | |
| Injectable; Injection; Dexketoprofen Trometamol 25 mg / ml (A. Menarini) | |
| Tablet, Film-Coated; Oral; Dexketoprofen Trometamol 25 mg (A. Menarini) | |
| Ketesse 25 mg x 1’s (A. Menarini) | |
| Ketesse 25 mg x 5 x 10’s (A. Menarini) | $ 29.14 |
| Ketesse 50 mg/2 mL x 5’s (A. Menarini) | $ 22.13 |
| Ketesse FC tab 25 mg 20’s (A. Menarini) | $ 11.31 |
| Ketesse infusion conc 25 mg/mL 2 mL x 1’s (A. Menarini) | $ 11.58 |
| Ketesse 12.5 | |
| Ketesse 25mg (Luxembourg, Switzerland) | |
| Ketesse 50mg/2ml (Oman, Switzerland) | |
| Ketesse SL (Poland) | |
| Keto-D (Bangladesh) | |
User reports
3 consumers reported useful
Was the Dexofen drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used , other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 3 | 100.0% |
1 consumer reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Dexofen drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 1 | 100.0% |
3 consumers reported time for results
To what extent do I have to use Dexofen before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.Please note, it doesn’t mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Dexofen. To get the time effectiveness of using Dexofen drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 day | 2 | 66.7% | |
| 1 week | 1 | 33.3% |
20 consumers reported age
| Users | % | ||
|---|---|---|---|
| 16-29 | 12 | 60.0% | |
| > 60 | 4 | 20.0% | |
| 46-60 | 2 | 10.0% | |
| 30-45 | 1 | 5.0% | |
| 1-5 | 1 | 5.0% |
| Cecilia Elisabeth | 04 Oct 2017 13:55 |
| As far as I know the medication is banned (at least in Sweden) because it\’s now classified as poison. I remember being prescribed this drug back in 2010-it then said on the list of side- effects (and so on) that you could die if you had had any alcohol 24 hours before taking medication, and 48 hours afterwards. The reason being, complete cramp and ultimately a type of suffocation in your respiratory system. It also said that you could not under any circumstance drive — I could barely stand up for more than 10 minutes without fainting. This drug is REALLY dangerous. | |
| michael burberry | 20 Jul 2017 03:07 |
| Dexofen is banned in the United and States and European Union. Why? |
Dexofen indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
sponsored
PO and IV
Prophylaxis of organ rejection in patients receiving allogenic liver, kidney, or heart transplants. Used in conjunction with adrenal corticosteroids. Used in conjunction with azathioprine or mycophenolate mofetil in heart and kidney transplant patients.
Topical
As second-line therapy for the short-term and noncontinuous long-term treatment of moderate to severe atopic dermatitis.
Unlabeled Uses
PO and IV
Prophylaxis of rejection for patients receiving bone marrow, pancreas, pancreatic island cell, and small bowel transplantation; treatment of autoimmune disease (ie, rheumatoid arthritis); prevention and treatment of acute graft-versus-host disease following hematopoietic stem cell transplantation; treatment of Crohn disease; treatment of pyoderma gangrenosum.
Topical
Treatment of vitiligo; cutaneous lupus erythematosis; facial, flexural, and intertriginous psoriasis; oral or genital lichen planus; pyoderma gangrenosum.
Особые указания
Следует соблюдать осторожность при назначении препарата пациентам пожилого возраста, пациентам с аллергическими реакциями, с системными заболеваниями соединительной ткани и пациентам с нарушением кроветворения. Следует проинформировать пациентов, что в случае появления побочных эффектов, а также при отсутствии клинического эффекта в течение 3-5 дней лечения необходимо сообщить об этом лечащему врачу
Следует проинформировать пациентов, что в случае появления побочных эффектов, а также при отсутствии клинического эффекта в течение 3-5 дней лечения необходимо сообщить об этом лечащему врачу.
Требуется особая осторожность при одновременном применении декскетопрофена с фенитоином, сульфонамидами и препаратами, снижающими свертываемость крови. Влияние на способность к вождению автотранспорта и управлению механизмами
Влияние на способность к вождению автотранспорта и управлению механизмами
Поскольку декскетопрофен может вызвать снижение способности к концентрации внимания, следует с осторожностью применять у пациентов, занимающихся потенциально опасными видами деятельности, требующими повышенного внимания и быстроты психомоторных реакций
Dexofen dosage
Tablet: General Population: According to the nature and severity of pain, the recommended dosage is generally 12.5 mg every 4-6 hrs or 25 mg every 8 hrs. The total daily dose should not exceed 75 mg. Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms.
Dexofen tablets are not intended for long-term use and the treatment must be limited to the symptomatic period.
Concomitant administration with food delays the absorption rate of the drug, thus in case of acute pain, it is recommended that administration is at least 30 min before meals.
Elderly: In elderly patients it is recommended to start the therapy at the lower end of the dosage range (50 mg total daily dose). The dosage may be increased to that recommended for the general population only after good general tolerance has been ascertained.
Hepatic Dysfunction: Patients with mild to moderate hepatic dysfunction should start therapy at reduced doses (50 mg total daily dose) and be closely monitored. Dexofen tablets should not be used in patients with severe hepatic dysfunction.
Renal Dysfunction: The initial dosage should be reduced to 50 mg total daily dose in patients with mildly impaired renal function. Dexofen tablets should not be used in patients with moderate to severe renal dysfunction.
Injection: Adults: The recommended dose is 50 mg every 8-12 hrs. If necessary, the administration can be repeated 6 hrs apart. The total daily dose should not exceed 150 mg.
Dexofen solution for injection or concentrate for solution for infusion is intended for short-term use and the treatment must be limited to the acute symptomatic period (not >2 days). Patients should be switched to an oral analgesic treatment when possible.
Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms.
In case of moderate to severe postoperative pain, Dexofen solution for injection or concentrate for solution for infusion can be used in combination with opioid analgesics, if indicated, at the same recommended doses in adults.
Elderly: No dosage adjustment is generally necessary in elderly patients. However, because of the physiological decline in renal function in elderly patients a lower dose is recommended in case of mild renal function impairment: 50 mg total daily dose.
Liver Disease: The dosage should be reduced to 50 mg total daily dose in patients with mild to moderate (Child-Pugh score 5-9) hepatic impairment and hepatic function should be closely monitored. Dexofen solution for injection or concentrate for solution for infusion should not be used in patients with severe hepatic dysfunction (Child-Pugh score 10-15).
Renal Dysfunction: The dosage should be reduced to 50 mg total daily dose in patients with mildly impaired renal function (CrCl 50-80 mL/min). Dexofen solution for injection or concentrate for solution for infusion should not be used in patients with moderate to severe renal dysfunction (CrCl
Administration: Injection: Dexofen solution for injection or concentrate for solution for infusion can be administered either by IM or IV route:
Intramuscular Use: The content of 1 ampoule (2 mL) of Dexofen solution for injection or concentrate for solution for infusion should be administered by slow injection deep into the muscle.
Intravenous Use:
Intravenous Infusion: The diluted solution, should be administered as a slow IV infusion, lasting 10-30 min. The solution must be always protected from natural daylight.
Intravenous Bolus: If necessary, the content of 1 ampoule (2 mL) of Dexofen solution for injection or concentrate for solution for infusion can be administered in a slow IV bolus over no less than 15 sec.
Instructions on Handling: When Dexofen is administered IM or as IV bolus, the solution should be injected after its removal from the colored ampoule. For administration as IV infusion, the solution should be diluted aseptically and protected from natural daylight.
Dexofen side effects
sponsored
The adverse reactions reported as at least possibly related with Dexofen trometamol in clinical trials, as well the adverse reactions reported after the marketing of Dexofen tablets and solution for injection or concentrate for solution for infusion are tabulated as follows, classified by system organ class and ordered by frequency:
Gastrointestinal: The most commonly observed adverse events are gastrointestinal in nature. Peptic ulcers, perforation or gastrointestinal bleeding, sometimes fatal, particularly in the elderly, may occur. Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melena, hematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn’s disease have been reported following administration. Less frequently, gastritis has been observed. Edema, hypertension and cardiac failure have been reported in association with NSAIDs treatment.
As with other NSAIDs the following undesirable effects may appear: Aseptic meningitis, which might predominantly occur in patients with systemic lupus erythematosus or mixed connective tissue disease; hematological reactions (purpura, aplastic and hemolytic anemia and rarely agranulocytosis and medullar hypoplasia).
Bullous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis (very rare).
Clinical trial and epidemiological data suggest that use of some NSAIDs (particularly at high doses and in long-term treatment) may be associated with a small increased risk of arterial thrombotic events (eg, myocardial infarction or stroke).